Despite its success, Viagra is not without side effects. However, Viagra is contraindicated in certain groups of patients, particularly those taking nitrates for sildenafil citrate and dapoxetine tablets chest pain, as the combination can lead to a dangerous drop in blood pressure. The most common adverse effects include headaches, flushing, indigestion, nasal congestion, and dizziness. These side effects are generally mild to moderate and transient. The medication is typically taken on an as-needed basis, about 30 minutes to an hour before sexual activity, and its effects can last for up to four hours.

Clinical trials and subsequent clinical experience have demonstrated the efficacy of Viagra in treating erectile dysfunction. Studies have shown that sildenafil improves erectile function in a significant proportion of men with ED, across various age groups and etiologies. Individuals with cardiovascular conditions, particularly those taking nitrate drugs for chest pain, are advised against using Viagra due to the risk of severe blood pressure drops. More serious but rare side effects can include priapism (a painful erection lasting longer than four hours), sudden hearing loss, or viagra generic brand vision loss.

Common adverse reactions include headaches, facial flushing, indigestion, nasal congestion, and, less commonly, changes in vision such as increased sensitivity to light or blurred vision. The drug is generally safe for most men, but it is not devoid of side effects. In conclusion, Viagra has made a significant impact on the treatment of erectile dysfunction since its introduction. Its discovery has not only provided a highly effective treatment option for millions of men with ED but has also opened new avenues of research into the use of PDE5 inhibitors for other medical conditions.

As research continues, the scope of Viagra's impact on medicine may expand even further. Viagra is administered orally and is available in 25 mg, 50 mg, and 100 mg doses. The recommended starting dose is typically 50 mg, doxycycline tablet price in india adjusted based on effectiveness and toleration. It should be taken approximately one hour before sexual activity, and its effects can last up to four hours. However, it is important to note that an erection will not occur just by taking the pill; sexual stimulation is required for Viagra to work.

Viagra has also been studied for other potential uses, such as the treatment of pulmonary arterial hypertension under the name Revatio. Additionally, research continues into its possible therapeutic roles in other conditions, demonstrating the versatility and potential of this molecule beyond its initial scope. The mechanism of action of Viagra is centered on its effects on the nitric oxide (NO) pathway within the penile tissue.

By inhibiting PDE5, sildenafil increases the levels of cGMP, leading to enhanced blood flow into the penis and facilitating the achievement and maintenance of an erection in response to sexual stimulation. Nitric oxide is a crucial mediator in the relaxation of smooth muscle and vasodilation (widening of blood vessels), which are essential for achieving an erection. Viagra works by inhibiting the enzyme phosphodiesterase type 5 (PDE5), which breaks down cyclic guanosine monophosphate (cGMP), a molecule that promotes relaxation of the smooth muscle in the corpus cavernosum of the penis.

It has helped break the stigma associated with erectile dysfunction, bringing more openness to discussions about sexual health among men. Viagra's introduction has also had significant social and cultural impacts.